|
KMID : 0191120220370090070
|
|
Journal of Korean Medical Science
2022 Volume.37 No. 9 p.70 ~ p.70
|
|
|
Booster BNT162b2 COVID-19 Vaccination Increases Neutralizing Antibody Titers Against the SARS-CoV-2 Omicron Variant in Both Young and Elderly Adults
|
|
Um Ji-Hye
Choi Youn-Young
Kim Ga-Yeon
Kim Min-Kyung
Lee Kyung-Shin
Sung Ho-Kyung
Kim Byung-Chul
Lee Yoo-Kyoung
Jang Hee-Chang
Bang Ji-Hwan
Chung Ki-Hyun
Oh Myoung-Don
Park Jun-Sun
Jeon Jae-Hyun
|
|
|
Abstract
|
|
|
|
Concerns about the effectiveness of current vaccines against the rapidly spreading severe acute respiratory syndrome-coronavirus-2 omicron (B.1.1.529) variant are increasing. This study aimed to assess neutralizing antibody activity against the wild-type (BetaCoV/Korea/KCDC03/2020), delta, and omicron variants after full primary and booster vaccinations with BNT162b2. A plaque reduction neutralization test was employed to determine 50% neutralizing dilution (ND50) titers in serum samples. ND50 titers against the omicron variant (median [interquartile range], 5.3 [< 5.0?12.7]) after full primary vaccination were lower than those against the wild-type (144.8 [44.7?294.0]) and delta (24.3 [14.3?81.1]) variants. Furthermore, 19/30 participants (63.3%) displayed lower ND50 titers than the detection threshold (< 10.0) against omicron after full primary vaccination. However, the booster vaccine significantly increased ND50 titers against BetaCoV/Korea/KCDC03/2020, delta, and omicron, although titers against omicron remained lower than those against the other variants (P < 0.001). Our study suggests that booster vaccination with BNT162b2 significantly increases humoral immunity against the omicron variant.
|
|
|
KEYWORD
|
|
|
COVID-19 Vaccine, Immunity, Antibodies, Omicron Variant, Republic of Korea
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
    
|